Oral manifestations in pediatric patients with nephritis lupus
Keywords:
Lupus nephritis, oral manifestations, patients, pediatricsAbstract
Objective: The aim of this study was describe the most frequent oral manifestations in patients with Nephritis Lupus (LN) as well as to make an updated bibliographic review of the classification, clinical treatment, treatment and dental management of the disease. Materials and method: A cross-sectional study was carried out with 9 children suffering from LN between the ages of 1 and 18 years, from the Pediatric Nephrology Service of the Hospital City Dr. Enrique Tejera, in Valencia, Venezuela, during the year 2016. Results: The results showed: more frequency of LN in female patients, with prevalence of 15 years old, and histological more frequent type III of LN. The oral manifestations found were: cheilitis, white spots, discoid erythema, geographical language, painless oral ulcers, cold sores, gingival enlargement, gingivitis, dry mouth, pallor of oral mucosa and glossitis. Conclusions: It is concluded that the patient with LN has oral manifestations related to the systemic disease that suffers.
Downloads
References
Hughes CT, Downey MS, Winkley GP. Systemic lupus erythematosus: a review for dental professionals. J Dent Hyg. 1998;72(2):35-40.
Scott JJX, Raghupathy P. Presence of thyroid antibodies in a child with systemic lupus erythematosus. Indian Pediatr 2005; 42:191-193
Brennan MT, Valerin MA, Napeñas JJ, Lockhart PB. Oral manifestations of patients with lupus erythomatosus. Dent Clin North Am. 2005;49(1):127-41.
Brunner HI, Gladman DD, Ibanez D, Urowitz MD, Silverman ED. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum. 2008;58(2):556-62.
Diniz-Da-Costa T, Centeno M, Pinto L, Marquez A, Mendes-Graca L. Lupus Eritematoso Sistemico e gravidez. Acta Med Port. 2012;25(6):446-53.
Hochberg MC. Updating the American College of Rheumatology revised criteria for the Classification of Systemic Lupus Erythematosus. Arthritis Rheum. 1997;40(9):1725.
Silvia V Lourencxo, Fabio R, Boggio P, Sotto MN, Vilela, et al. (2007) Lupus erythematosus: Clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate. J Cutan Pathol 34(7): 558-564.
Pohl D, Benseler S. Systemic inflammatory and autoimmune disorders. Handb Clin Neurol. 2013;112: 1243-52.
Binder E, Edelbauer M. Use of biomarkers in the management of children with lupus. Curr Rheumatol Rep. 2013; 15(3):312.
Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, Harley JB. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003; 349(16):1526–33.
Sánchez-Vegazo I, Teruel C, Menéndez J. Nefritis Lúpica. Revista Española de Patología 2008; 35 (3): 269-278.
Mok CC, Yap DY, Navarra SV, Liu ZH, Zhao MH, Lu L et al. Overview of lupus nephritis management guidelines and perspective from Asia. Nephrology 2014; 19 (1) 11-20.
Balow J, Austin H. Renal disease in systemic lupus erythematosus. Rheumatic Disease Clinics of North America 2008; 14: 117–133.
Álvarez V D, Cera CD, Gastelbondo AR. Nefritis Lúpica en niños de Bogotá: hallazgos clínicos y correlación clínico patológica. Revista de Pediatría 2002; 37 (1): 1- 4.
Beltrán G, Mejía N; Martínez M, Martínez P. Nefropatía lúpica en niños. Correlación clínico patológica en una institución pediátrica de Bogotá – Colombia. Rev. Fac Med (Bogotá) 2004; 52(2):121-131.
Beltrán G, Mejía N; Martínez M, Martínez P. Nefropatía lúpica en niños. Correlación clínico patológica en una institución pediátrica de Bogotá – Colombia. Rev. Fac Med (Bogotá) 2004; 52(2):121-131.
Espinosa Garriga G, Cervera Segura R. New concepts in the treatment of lupic nephropathy. Rev Clin Esp. 2007;207(11):570-2.
Diouf B, Toure AO, Ka MM, Pouye A, Diop TM. Management of lupus nephritis in Senegal. Dakar Med. 1997;42(2):145-8.
Vachvanichsanong P, McNeil E. Pediatric lupus nephritis: more options, more chances? Lupus.2013;22(6):545-53.
Yong JL, Killingsworth MC, Lai K. Renal biopsy pathology in a cohort of patients from southwest Sydney with clinically diagnosed systemic lupus erythematosus. Int J Nephrol Renovas Dis. 2013;6:15-26.
Amin F, Aziz S. Development and Management of a Periapical lesion in a known case of Systemic Lupus Erythematosus – A Case Report. J Dent Health Oral Disord Ther. 2017;6(1):00185
Jimson S, Balachader N, Anita N, Babu R. Inmunologically mediated oral disease. J Pharm Bioallied Sci. 2015:7(Suppl 1):S209-12.
Schiodt M, Halberg P, Hentzer B. A clinical study of 32 patients with Oral Discoid Lupus Erythematosus. Int J Oral Surg. 1978;7:85–94.
Wood NH, Shangase SL. Characterising oral lesions in patients who presented with chronic vesiculobullous lesions during a 10-year period. SADJ 2012;67(7):359-63.
Chi AC, Neville BW, Krayer JW, Gonsalves WC. Oral manifestations of systemic disease. Am Fam Physician. 2010; 82(11):1381-88.
Gonsalves WC, Chi AC, Neville BW. Common oral lesions: Part I. Superficial mucosal lesions. Am Fam Physician. 2007;75(4):501-7.
Callen JP. Oral manifestations of collagen vascular disease. Semin Cutan Med Surg. 1997;16(4):323-7.
De Oliveira MA, De Rezende NP, Maia CM, Gallottini M. Primary Sjogren syndrome in a 2-year-old patient: a role of the dentist in diagnosis and dental management with a 6-year-old follow up. Int J Paediatr Dent 2011;21(6):471-5.
Lopez-Labady J, Villaroel-Dorrego M, Gonzalez N, Perez R, Mata M. Oral manifestations of systemic and cutaneous lupus erythematosus in a Venezuelan population. J Oral Pathol Med. 2007;36(9):524-7.
Benatti BB, Carvalho MD, Games BP (2003) Importance of differential diagnosis in endodontic-periodontic lesions: case reports. Gen Dent 51(3): 246-248.
Lorenzo-Calabria J, Grau D, Silvestre FJ, Hernandez- Mijares A. Management of patients with adrenocortic insufficiency in the dental clinic. Med Oral. 2003;8(3):207- 14.
Morales C, Carol L, Barrios Emil J. Caracterización de pacientes pediátricos con nefritis lúpica que consultan al hospital infantil Napoleón Franco pareja de Cartagena entre abril del 2000 y abril del 2011. Universidad de Cartagena. Facultad de medicina. Departamento de postgrado. Colombia. [Internet]. Available in: http://190.242.62.234:8080/jspui/bitstream/11227/1772/1 /NEFRITIS%20LUPICA.%20Carol%20Morales%20Cont reras..pdf
Alonzo MD, Llorca J, Martinez–Vasquez F, Miranda- Filloy JA, Diaz de Teran T, Dierssen T, Vazquez- Rodriguez TR, Gomez-Acebo I, Blanco R, Gonzalez- Gay MA.. Systemic lupus erythematosus in northwestern Spain: a 20–year epidemiologic study. Medicine. 2011; 90(5):350-8.
Yacoub Wasef SZ. Gender differences in systemic lupus erythematosus. Gend Med. 2004;1(1):12–7.
Sundel RP, Solomons L, Lisk L. Aspreva Lupus Management Study (ALMS) Group. Efficacy of Mycophenolate Mofetil in adolescent patients with Lupus Nephritis: Evidence from a two-phase prospective randomized trial. Lupus. 2012; 21:1433-43.
Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, Doménech I, Aydintug AO, Jedryka-Góral A, de Ramón E, et al. Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1000 patients. Medicine. 1993; 72(2): 113- 24.
Pinto LF, Guerra L, González JR, Pérez A, Velásquez CJ, Felipe O, et al. Lupus Eritematoso Sistémico: análisis del comportamiento clínico en una población de Medellín. Rev Col Reum 1997;4:170-3.
Senior JM, Pinto LF, Uribe O, De la Cruz OF, Ramírez LA. Nefropatía lúpica: correlación clinico-patológica y respuesta al tratamiento con pulsos de ciclofosfamida. Rev Col Reumatol. 1994; 1: 19-27.
Pereira MV, Revelo MP, Bambirra EA. Lupic nephropathy in childhood: morphologic analysis of 18 cases.J Pediatr (Rio J). 1996;72(1):32-4.
Ferreira M, Orta N, Uviedo C, Coronel V, Lara E, Ortega M, Domínguez L, Marcano H, Pinto JA, Romero S, Planchart A. Aspectos clínico epidemiológicos de la nefritis lupica en pediatría. Estudio de 12 años. Archivos Venezolanos de Puericultura y Pediatria 2014; Vol 77(2):60 – 64
Alonso L, Naranjo G, Alberto L, Gómez R. Lupus eritematoso sistémico de inicio tardío. 2008; 15(3):168- 85
Niaudet P. Treatment of lupus nephritis in children. Pediatr Nephrol. 2000 Feb;14(2):158-66.
Gottlieb BS, Ilowite NT. Systemic lupus erythematosus in children and adolescents. Pediatr Rev. 2006; 27(9): 323-30.
Wananukul S, Watana D, Pongprasit P. Cutaneous manifestation of childhood systemic lupus erythematosus. Pediatr Dermatol. 1998; 15(5):342-6.
Proctor R, Kumar N, Stein A, Moles D, Porter S. Oral and dental aspects of chronic renal failure. J Dent Res. 2005;84(3):199- 208
Espitia S, Castillo L, Carbonel B, Mórelo A, Pacheco M. Asociación entre la disminución de los niveles de flujo salival y xerostomía en pacientes con insuficiencia renal crónica hemodializados de la Unidad Renal Nefrología LTDA, de la ciudad de Santa Marta. Revista de la Facultad de Ciencias de la Salud. 2007; 4 (2): 100-1.
Summers SA, Tilakaratne WM, Fortune F, Ashman N. Renal Disease and the Mouth. Am J Med. 2007; 120(7): 568–73
Díaz A, Hernández J, Pérez C. Alteraciones bucodentales en niños con insuficiencia renal crónica y trasplantes renales. Acta Odontológica Venezolana. 2010; 48 (2): 1-11.
Burge SM, Frith PA, Juniper RP, Wojnarowska F. Mucosal involvement in Systemic and chronic cutaneous lupus erythematosus. Br J Dermatol. 1989; 121(6):727- 41.
Louis PJ, Fernández R. Review of systemic lupus erythematosus. Oral Surg Oral Med Oral Pathol. 2001;91(5):512-6.
Meyer U, Kleinheinz J, Handschel J, Kruse-Losler B, Weingart D, Joos U. Oral findings in three different groups of immunocompromised patients. J Oral Pathol Med. 2000;29(4):153-8.
Ortega LM, Schultz DR, Lenz O, Pardo V, Contreras GN. Review: Lupus Nephritis: pathologic features, epidemiology and guide to therapeutic decisions. Lupus. 2010;19(5):567-74.
Al-Matairi KD, Al-Kahrani MS, Bahlas SM, Kayal RA, Zawawi KH. Periodontal findigs in systemic lupus erythematosus patients and healthy controls. Saudi Med J 2015:36(4):463-8.
Mejía E. MG. Fisiopatología del lupus eritematoso sistémico. Rev Med Invest [Internet]. 2013 [cited 29 Sept 2015];1(1). Available in: http://www.elsevier.es/es- revista-revista-medicina-e-investigacion-353-articulo- fisiopatologia-del-lupus-eritematoso-sistemico-90165398
Mays JW, Sarmadi M, Moutsopoulos NM. Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management. J Evid Based Dent Pract 2012;12(3 Suppl):265-82.
Orteu CH, Buchanan JAG, Huychinson I, Leigh IM, Bull RH. Systemic lupus erythematosus presenting with oral mucosal lesions: easily missed? Br J Dermatol 2001; 144(6):1219-23.
Babu RA, Chandrashekar P, Kumar KK, Reddy GS, Chandra KL, Rao V, Reddy B. A study on oral mucosal lesions in 3500 patients with dermatological diseases in South India. Ann Med Health Sci Res 2014;4(Suppl 2):S84-93.
Ranginwala AM, Chalishazar MM, Panja P, Buddhdev KP, Kale HM. Oral discoid lupus erythematosus: A study of twenty-one cases. J Oral Maxillofac Pathol. 2012;16(3):368-73
Downloads
Published
Issue
Section
License
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) posterior al proceso de aprobación del manuscrito, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada.
