Prophylactic analgesic effect of paracetamol and ibuprofen in the extraction of teeth in children
Keywords:
Paracetamol, Ibuprofen, Analgesic prophylaxisAbstract
Objective: To evaluate the prophylactic analgesic effect of paracetamol and ibuprofen administered before the extraction of deciduous teeth in children. Materials and methods: Sixty children of 6 to 8 years of age were evaluated and attended the Dental Center of the Faculty of Dentistry of the University of San Martín de Porres, which were distributed in three groups, each of 20 children: group paracetamol, ibuprofen group and the control group. In the first two, the corresponding drug was administered orally 30 minutes before surgery (paracetamol 15 mg / kg or Ibuprofen 10 mg / kg). The following variables were evaluated: presence of pain, time of presence of pain, intensity of pain, and time elapsed for rescue analgesia. Results: Significant differences were found in the presence of pain variable and in the time of presence of pain among the 3 groups. There was no significance between the variables studied between the two groups with drugs. Conclusions: Analgesic prophylaxis is an effective alternative to conventional post-surgical pharmacological treatment. Ibuprofen and Paracetamol are drugs with similar efficacy for this purpose, despite presenting different pharmacological action.
Downloads
References
IASP, 1994. Part III: (pp 209-214). Classification of Chronic Pain, Second Edition, IASP Task Force on Taxonomy, edited by H. Merskey and N. Bogduk, ISAP Press, Seattle, 1994. http://www.iasp- pain.org.
González de Mejía N.: Postoperative multimodal analgesia. Rev Soc Esp Dolor, 2005; 12:112-118.
Tovar MA. Dolor en niños. Colombia Médica. 2005; 36(4): 62-68.
Hartling L, Ali S, Dryden DM, Chordiya P, Johnson DW, Plint AC, Stang A, McGrath PJ, Drendel AL, How Safe Are Common Analgesics for the Treatment of Acute Pain for Children? A Systematic Review. Pain Res Manag. 2016; 2016:5346819.
Primosch RE, Nichols DL, Courts FJ, Comparison of preoperative ibuprofen, acetaminophena and placebo administration on the parental report of postextraction pain in children. Pediatr Dent.1995; 17(3):187-91
Chumpitaz Cerrate V. Comparación de Diclofenaco y Ketorolaco para prevenir el dolor posterior a cirugía de tercera molar retenida [Tesis para optar el grado de Magister en Farmacología]. Lima: Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos; 2007.
Esquivel Velásquez G. Efectividad del diclofenaco y Ketoprofeno como profilaxis analgésica en cirugía de terceras molares retenidas [Tesis para optar el título de Cirujano Dentista]. Lima: Facultad de Odontología, Universidad Nacional Mayor de San Marcos; 2009.
Yamaguchi A, Sano K, Effectiveness of preemptive analgesia on postoperative pain following third molar surgery: Review of literatures. Japan Dent Science Review. 2013; 49(4): 131-138
Goodman Gilman A. Las bases farmacológicas de la terapéutica. 8º ed. Buenos Aires. Médica Panamericana. 1991.
Litter Manuel. Compendio de farmacología. 5º ed. Buenos Aires. El Ateneo. 2001.
Milani GP, Benini F, Dell'Era L, Silvagni D, Podestà AF, Mancusi RL, Fossali Ef; Pierre GROUP STUDY. Acute pain management: acetaminophen and ibuprofen are often under- dosed. Eur J Pediatr. 2017; 176(7):979-982.
Woolf C, Chong M. Preemptive analgesia— treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg 1993; 77:362-79.
McQuay H, Dickenson A. Implications of nervous system plasticity for pain management. Anaesthesia 1990; 45:101-2.
Paracetamol for pain relief after surgical removal of lower wisdom teeth (Protocol) Weil K, Afzal Z, Esposito M, Worthington HV, van Wijk AJ, Hooper L, Coulthard P. Cochrane Database Syst Rev. 2007; 18(3): CD004487
Attar S1, Bowles WR, Baisden MK, Hodges JS, McClanahan SB. Evaluation of pretreatment analgesia and endodontic treatment for postoperative endodontic pain. J Endod. 2008; 34(6):652-5.
Dionne R, Campbell R, Cooper S, Hall D, Buckingham B, Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen and Acetaminophen plus Codeine. J Clin Pharmacol. 1983; 23:37-43.
Viitanen H, Tuominen N, Nikanne E, Annila P, Analgesic eficacy of rectal acetaminophen and ibuprofen alone or in combination for paediatric day-case adenoidectomy. British Journal of Anaesthesia 2003; 91(3): 363-7.
Charles C, Matt B, Hamilton M, Katz B, A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient. Otolaryngol Head Neck Surg 1997; 117:76-82.
Lesko SM1, Mitchell AA, An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial. JAMA. 1995; 273(12):929-33.
Vogel R, Desjardins J, Major K, Comparison of Presurgical and Immediate Postsurgical Ibuprofen on Postoperative Periodontal Pain. J Periodontol. 1992; 63(11):914-18.
Steen Law SL, Southard KA, Law AS, Logan HL, Jakobsen JR. An evaluation of preoperative ibuprofen for treatment of pain associated with orthodontic separator placement. Am J Orthod Dentofacial Orthop. 2000 Dec;118(6):629-35.
Moore RA, Derry S, Wiffen PJ, Straube S, Aldington DJ. Overview review: Comparative efficacy of oral Ibuprofen and Paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain. 2015; 19(9):1213-23.
Kanabar DJ, A clinical and safety review of Paracetamol and Ibuprofen in children. Inflammopharmacology. 2017;25(1):1-9.
Ashley, P.F., Parekh, S., Moles, D.R., Anand, P., Behbehani, A. Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. Cochrane Database Syst Rev. 2016; (8):CD008392
Welchek C, Mastrangelo L, Sinatra R, Martinez R, Qualitative and Quantitative Assessment of Pain. En Sinatra R. Acute Pain Mangement. Cambridge University Press, 2009. p.147-171
Jackson D, Moore P, Hargreaves K. Preoperative nonsteroidal anti-inflammatory medication for the prevention of postoperative dental pain. J Am Dent Assoc 1989;119:641-7.
Shirvani A, Shamszadeh S, Eghbal MJ, Marvasti LA, Asgary S. Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis—a systematic review and meta-analysis. Clin Oral Investig. 2017 Jan;21(1):43-52.
Liu C1, Ulualp SO, Outcomes of an Alternating Ibuprofen and Acetaminophen Regimen for Pain Relief After Tonsillectomy in Children. Ann Otol Rhinol Laryngol. 2015;124(10):777-81.
Merry AF, Edwards KE, Ahmad Z, Barber C, Mahadevan M, Frampton C, Randomized comparison between the combination of Acetaminophen and Ibuprofen and each constituent alone for analgesia following tonsillectomy in children. Can J Anaesth. 2013; 60(12):1180-9.
Downloads
Published
Issue
Section
License
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) posterior al proceso de aprobación del manuscrito, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada.