Artificial intelligence to improve the diagnosis and treatment in Orthodontics: advances, challenges and perspectives. Literature review
DOI:
https://doi.org/10.24265/kiru.2025.v22n3.04Keywords:
Artificial Intelligence; Diagnosis; Treatment; OrthodonticsAbstract
The objective of the study was to analyze the impact of artificial intelligence (AI) on diagnosis and treatment in orthodontics, evaluating its advances, benefits, and challenges through a review of recent scientific literature. A bibliographic review was carried out in databases such as PubMed, Scopus, Science Direct, and Google Scholar, using keywords in Spanish and English along with Boolean operators. They were included 42 articles published between 2020 and 2025 that addressed the use of AI in orthodontics, prioritizing studies with scientific and methodological relevance. The implementation of AI in orthodontics has optimized diagnosis and treatment planning through techniques such as convolutional neural networks (CNN), machine learning (ML), and big data-based prediction models. These tools have demonstrated high accuracy in the detection of cephalometric anatomical points, growth analysis, and prediction of orthodontic and orthognathic treatment outcomes. Furthermore, AI has improved clinical decision making, reducing diagnostic time and increasing treatment efficiency. AI has shown high potential to improve diagnosis and treatment in orthodontics, achieving accuracy comparable to that of human experts in identifying anatomical structures and planning treatments. However, its application faces barriers such as lack of standardization, ethical concerns about data privacy, and the need for broader clinical validations. As these challenges should be overcome, AI will establish itself as a key tool in orthodontic practice.
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References
Liu J, Chen Y, Li S, Zhao Z, Wu Z. Machine learning in orthodontics: Challenges and perspectives. Adv Clin Exp Med. 2021;30(10):1065–1074. doi: 10.17219/acem/138702.
Surendran A, Daigavane P, Shrivastav S, Kamble R, Sanchla AD, Bharti L, et al. The Future of Orthodontics: Deep Learning Technologies. Cureus. 2024 Jun 10;16(6):e62045. doi: 10.7759/cureus.62045
Kurt Demirsoy K, Buyuk SK, Bicer T. How reliable is the artificial intelligence product large language model ChatGPT in orthodontics? Angle Orthod. 2024 Nov 1;94(6):602-607. doi: 10.2319/031224-207.1.
Wong K, Lam X, Jiang Y, Yeung A, Lin Y. Artificial intelligence in orthodontics and orthognathic surgery: a bibliometric analysis of the 100 most-cited articles. HFM. 2023;19(1):38. doi: 10.1186/s13005-023-00383-0
Polizzi A, Boato M, Serra S, D'Antò V, Leonardi R. Applications of artificial intelligence in orthodontics: a bibliometric and visual analysis. Clin Oral Investig. 2025 Jan 16;29(1):65. doi: 10.1007/s00784-025-06158-y.
Dipalma G, Inchingolo AD, Inchingolo AM, Piras F, Carpentiere V, Garofoli G, et al. Artificial Intelligence and Its Clinical Applications in Orthodontics: A Systematic Review. Diagnostics (Basel). 2023 Dec 15;13(24):3677. doi: 10.3390/diagnostics13243677.
Bor S, Kotan S. The Influence of Artificial Intelligence in Orthodontics. J Dent Fac Usak Univ. 2023;2(1):14-9.
Gupta S, Verma S, Chauhan AK, Roy MS, Rajkumari W, Sahgal C. Knowledge, attitude, and perception of orthodontic students, and orthodontists regarding role of artificial intelligence in field of orthodontics-An online cross-sectional survey. J World Fed Orthod. 2025 Feb;14(1):3-11. doi: 10.1016/j.ejwf.2024.08.002.
Gracea RS, Winderickx N, Vanheers M, Hendrickx J, Preda F, Shujaat S, et al. Artificial intelligence for orthodontic diagnosis and treatment planning: A scoping review. J Dent. 2025 Jan;152:105442. doi: 10.1016/j.jdent.2024.105442.
Tahir K, Abul Barakaat A, Fida M, Sukhia R. In the Contemporary Era of Artificial Intelligence, the Trajectory of Orthodontics: Past and Future Perspectives–A Narrative Review. J Calif Dent Assoc. 2024;52(1):2400420. doi: 10.1080/19424396.2024.2400420
Monill-González A, Rovira-Calatayud L, d'Oliveira NG, Ustrell-Torrent JM. Artificial intelligence in orthodontics: Where are we now? A scoping review. Orthod Craniofac Res. 2021 Dec;24 Suppl 2:6-15. doi: 10.1111/ocr.12517.
Khanagar SB, Al-Ehaideb A, Vishwanathaiah S, Maganur PC, Patil S, Naik S, et al. Scope and performance of artificial intelligence technology in orthodontic diagnosis, treatment planning, and clinical decision-making - A systematic review. J Dent Sci. 2021 Jan;16(1):482-492. doi: 10.1016/j.jds.2020.05.022.
Strunga M, Urban R, Surovková J, Thurzo A. Artificial Intelligence Systems Assisting in the Assessment of the Course and Retention of Orthodontic Treatment. Healthcare (Basel). 2023 Feb 25;11(5):683. doi: 10.3390/healthcare11050683
Büyük SK, Hatal S. Artificial Intelligence and Machine Learning in Orthodontics. Ortadogu Tıp Derg. 2019;11(4): 517-523.
Al Turkestani N, Bianchi J, Deleat-Besson R, Le C, Tengfei L, Prieto JC, et al. Clinical decision support systems in orthodontics: A narrative review of data science approaches. Orthod Craniofac Res. 2021 Dec;24 Suppl 2(Suppl 2):26-36. doi: 10.1111/ocr.12492.
Akdeniz S, Tosun M. A review of the use of artificial intelligence in orthodontics. JECM. 2021; 38(3s):157-162.
Hussain M, Fatima S, Reddy K, Ramya Y, Betha S, Kauser A, et al. Artificial intelligence in orthodontics: A review. International J. Health Sci. 2022;6(S2):9378-9383. doi: 10.53730/ijhs.v6nS2.7445
Ahmed N, Chethana A, Aymen U, Rahul N. Artificial intelligence in orthodontics: A way towards modernization. IP Indian J Orthod Dentofacial Res. 2023;9(1):3-7. doi: 10.18231/j.ijodr.2023.002
Kunz F, Stellzig-Eisenhauer A, Boldt J. Applications of Artificial Intelligence in Orthodontics—An Overview and Perspective Based on the Current State of the Art. Applied Sciences. 2023;13(6):3850. doi: 10.3390/app13063850
Siddiqui TA, Sukhia RH, Ghandhi D. Artificial intelligence in dentistry, orthodontics and Orthognathic surgery: A literature review. J Pak Med Assoc. 2022 Feb;72(Suppl 1)(2):S91-S96. doi: 10.47391/JPMA.AKU-18.
Hung H, Wang Y, Wang Y. Applications of artificial intelligence in orthodontics. TJO. 2020;32(2):3. doi: 10.38209/2708-2636.1005
Leonardi R, Vaiid N. Artificial Intelligence in Orthodontics: Concerns, Conjectures, and Ethical Dilemmas. Int Dent J. 2025 Feb;75(1):20-22. doi: 10.1016/j.identj.2024.11.002
Rahim A, Khatoon R, Khan TA, Syed K, Khan I, Khalid T, et al. Artificial intelligence-powered dentistry: Probing the potential, challenges, and ethicality of artificial intelligence in dentistry. Digit Health. 2024 Nov 11;10:20552076241291345. doi: 10.1177/20552076241291345.
Nordblom NF, Büttner M, Schwendicke F. Artificial Intelligence in Orthodontics: Critical Review. J Dent Res. 2024 Jun;103(6):577-584. doi: 10.1177/00220345241235606.
Liu J, Zhang C, Shan Z. Application of Artificial Intelligence in Orthodontics: Current State and Future Perspectives. Healthcare (Basel). 2023 Oct 18;11(20):2760. doi: 10.3390/healthcare11202760.
Yellu R, Kukalakunta Y, Thunki P. Artificial Intelligence in Orthodontics: Current Trends and Future Directions. JBAI. 2024;4(1):50-55.
Bichu YM, Hansa I, Bichu AY, Premjani P, Flores-Mir C, Vaid NR. Applications of artificial intelligence and machine learning in orthodontics: a scoping review. Prog Orthod. 2021 Jul 5;22(1):18. doi: 10.1186/s40510-021-00361-9.
Albalawi F, Alamoud K. Trends and application of artificial intelligence technology in orthodontic diagnosis and treatment planning—A review. Applied Sciences. 2022;12(22):11864. doi: 10.3390/app122211864
Subramanian AK, Chen Y, Almalki A, Sivamurthy G, Kafle D. Cephalometric Analysis in Orthodontics Using Artificial Intelligence-A Comprehensive Review. Biomed Res Int. 2022 Jun 16;2022:1880113. doi: 10.1155/2022/1880113.
M‘hamed Jihed, Ines Dallel, Samir Tobji, Adel Ben Amor. The Impact of Artificial Intelligence on Contemporary Orthodontic Treatment Planning - A Systematic Review and Meta-Analysis. Sch J Dent Sci, 2022 Jun 9(5): 70-87. doi: 10.36347/sjds.2022.v09i05.001
Del Real A, Del Real O, Sardina S, Oyonarte R. Use of automated artificial intelligence to predict the need for orthodontic extractions. Korean J Orthod. 2022;52:102-111. doi: 10.4041/kjod.2022.52.2.102
Tanikawa C, Yamashiro T. Development of novel artificial intelligence systems to predict facial morphology after orthognathic surgery and orthodontic treatment in Japanese patients. Sci Rep. 2021;11:15853. doi: 10.1038/s41598-021-95002-w
Ryu J, Lee Y, Mo S, Lim K, Jung S, Kim T. Application of deep learning artificial intelligence technique to the classification of clinical orthodontic photos. BMC Oral Health. 2022; 22(1):454. doi: 10.1186/s12903-022-02466-x
Kök H, Acilar AM, İzgi MS. Usage and comparison of artificial intelligence algorithms for determination of growth and development by cervical vertebrae stages in orthodontics. Prog Orthod. 2019 Nov 15;20(1):41. doi: 10.1186/s40510-019-0295-8.
Lee JM, Moon JH, Park JA, Kim JH, Lee SJ. Factors influencing the development of artificial intelligence in orthodontics. Orthod Craniofac Res. 2024 Dec;27 Suppl 2(Suppl 2):6-12. doi: 10.1111/ocr.12806.
Li P, Kong D, Tang T. Orthodontic treatment planning based on artificial neural networks. Scientific Rep. 2019;9(1):1–9. doi: 10.1038/s41598-018-38439-w
Seo H, Hwang J, Jeong T, Shin J. Comparison of Deep Learning Models for Cervical Vertebral Maturation Stage Classification on Lateral Cephalometric Radiographs. J Clin Med. 2021 Aug 15;10(16):3591. doi: 10.3390/jcm10163591.
Kim EG, Oh IS, So JE, Kang J, Le VNT, Tak MK, et al. Estimating Cervical Vertebral Maturation with a Lateral Cephalogram Using the Convolutional Neural Network. J Clin Med. 2021 Nov 19;10(22):5400. doi: 10.3390/jcm10225400.
Kim H, Shim E, Park J, Kim YJ, Lee U, Kim Y. Web-based fully automated cephalometric analysis by deep learning. Comput Methods Programs Biomed. 2020;194:105513. doi: 10.1016/j.cmpb.2020.105513.
Guo Y-C, Han M, Chi Y, Long H, Zhang D, Jang J, et al. Accurate age classification using manual method and deep convolutional neural network based on orthopantomogram images. Int J Legal Med. 2021;135(4):1589-1597. doi: 10.1007/s00414-021-02542-x
Naik N, Hameed BMZ, Shetty DK, Swain D, Shah M, Paul R, et al. Legal and Ethical Consideration in Artificial Intelligence in Healthcare: Who Takes Responsibility? Front Surg. 2022 Mar 14;9:862322. doi: 10.3389/fsurg.2022.862322.
Miranda F, Barone S, Gillot M, Baquero B, Anchling L, Hutin N, et al. Artificial intelligence applications in orthodontics. J Calif Dent Assoc. 2023;51(1):2195585. doi: 10.1080/19424396.2023.2195585
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